Key Laboratory of Cardiovascular & Cerebrovascular Medicine, Drug Target & Drug Discovery Center, School of Pharmacy, Nanjing Medical University, Nanjing, Jiangsu Province 211166, PR China. Department of Clinical Pharmacology, School of Pharmacy, Nanjing Medical University, Nanjing, Jiangsu Province 211166, PR China. Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, 980-8578, Japan. Key Laboratory of Cardiovascular & Cerebrovascular Medicine, Drug Target & Drug Discovery Center, School of Pharmacy, Nanjing Medical University, Nanjing, Jiangsu Province 211166, PR China. Electronic address: fenghan169@njmu.edu.cn.